CD22-Antagonists with Nanomolar Potency: The Synergistic Effect of Hydrophobic Groups at C-2 and C-9 of Sialic Acid Scaffold

In earlier studies, we identified the C-9 amido derivative 1 (9-(4'-hydroxy-4-biphenyl)acetamido-9-deoxy-Neu5Gcα2-6GalOMP) and the C-9 amino derivative 2 (9-(4'-hydroxy-4-biphenyl)methylamino-9-deoxy-Neu5Gcα2-6GalOMP) have the most promising affinity for mouse CD22 and human CD22, respecti...

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Detalhes bibliográficos
Main Authors: Abdu-Allah, Hajjaj H. M., Watanabe, Kozo, Completo, Gladys C., Sadagopan, Magesh, Hayashizaki, Koji, Takaku, Chiaki, Tamanaka, Taichi, Takematsu, Hiromu, Kozutsumi, Yasunori, Paulson, James C., Tsubata, Takeshi, Ando, Hiromune, Ishida, Hideharu, Kiso, Makoto
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816717/
https://ncbi.nlm.nih.gov/pubmed/21349726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.01.060
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