CD22-Antagonists with Nanomolar Potency: The Synergistic Effect of Hydrophobic Groups at C-2 and C-9 of Sialic Acid Scaffold

In earlier studies, we identified the C-9 amido derivative 1 (9-(4'-hydroxy-4-biphenyl)acetamido-9-deoxy-Neu5Gcα2-6GalOMP) and the C-9 amino derivative 2 (9-(4'-hydroxy-4-biphenyl)methylamino-9-deoxy-Neu5Gcα2-6GalOMP) have the most promising affinity for mouse CD22 and human CD22, respecti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Abdu-Allah, Hajjaj H. M., Watanabe, Kozo, Completo, Gladys C., Sadagopan, Magesh, Hayashizaki, Koji, Takaku, Chiaki, Tamanaka, Taichi, Takematsu, Hiromu, Kozutsumi, Yasunori, Paulson, James C., Tsubata, Takeshi, Ando, Hiromune, Ishida, Hideharu, Kiso, Makoto
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816717/
https://ncbi.nlm.nih.gov/pubmed/21349726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.01.060
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