Improving the Endosomal Escape of Cell-Penetrating Peptides and Their Cargos: Strategies and Challenges

Cell penetrating peptides (CPPs) can deliver cell-impermeable therapeutic cargos into cells. In particular, CPP-cargo conjugates tend to accumulate inside cells by endocytosis. However, they often remain trapped inside endocytic organelles and fail to reach the cytosolic space of cells efficiently....

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Erazo-Oliveras, Alfredo, Muthukrishnan, Nandhini, Baker, Ryan, Wang, Ting-Yi, Pellois, Jean-Philippe
Format: Artigo
Langue:Inglês
Publié: MDPI 2012
Sujets:
Review
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816665/
https://ncbi.nlm.nih.gov/pubmed/24223492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph5111177
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