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Discovery of ‘molecular switches’ within a GIRK activator scaffold that afford selective GIRK inhibitors
This letter describes a multi-dimensional SAR campaign based on a potent, efficacious and selective GIRK1/2 activator (~10-fold versus GIRK1/4 and inactive on nonGIRK 1-containing GIRKs, GIRK 2 or GIRK2/3). Further chemical optimization through an iterative parallel synthesis effort identified multi...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3816575/ https://ncbi.nlm.nih.gov/pubmed/23838260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.06.023 |
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