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Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation
Preclinical drug development for visceral pain has largely relied on quantifying pseudoaffective responses to colorectal distension (CRD) in restrained rodents. However, the predictive value of changes in simple reflex responses in rodents for the complex human pain experience is not known. Male rat...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3816530/ https://ncbi.nlm.nih.gov/pubmed/18538929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2008.04.018 |
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