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Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation
Preclinical drug development for visceral pain has largely relied on quantifying pseudoaffective responses to colorectal distension (CRD) in restrained rodents. However, the predictive value of changes in simple reflex responses in rodents for the complex human pain experience is not known. Male rat...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3816530/ https://ncbi.nlm.nih.gov/pubmed/18538929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2008.04.018 |
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