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Phase I study of temsirolimus in combination with EKB-569 in patients with advanced solid tumors
PURPOSE: Activation of EGFR can stimulate proliferative and survival signaling through mTOR. Preclinical data demonstrates synergistic activity of combined EGFR and mTOR inhibition. We undertook a phase I trial of temsirolimus (T, an mTOR inhibitor) and EKB-569 (E, an EGFR inhibitor) to determine th...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3816525/ https://ncbi.nlm.nih.gov/pubmed/21881915 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-011-9742-1 |
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