Iterative Correction of Hi-C Data Reveals Hallmarks of Chromosome Organization

Extracting biologically meaningful information from chromosomal interactions obtained with genome-wide chromosome conformation capture (3C) analyses requires elimination of systematic biases. We present a pipeline that integrates a strategy for mapping of sequencing reads and a data-driven method fo...

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Bibliographic Details
Main Authors: Imakaev, Maxim, Fudenberg, Geoffrey, McCord, Rachel Patton, Naumova, Natalia, Goloborodko, Anton, Lajoie, Bryan R., Dekker, Job, Mirny, Leonid A
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816492/
https://ncbi.nlm.nih.gov/pubmed/22941365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.2148
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