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MDMX contains an autoinhibitory sequence element
MDM2 and MDMX are homologous proteins that bind to p53 and regulate its activity. Both contain three folded domains and ∼70% intrinsically disordered regions. Previous detailed structural and biophysical studies have concentrated on the isolated folded domains. The N-terminal domains of both exhibit...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3816421/ https://ncbi.nlm.nih.gov/pubmed/24127580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317398110 |
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