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Synthesis of a Library of “Lead-Like” γ-Lactams by a One Pot, Four-Component Reaction
The synthesis of a pilot scale library of 116 structurally diverse γ-lactams is reported. The library core structure emanates from a γ-lactam forming one-pot, four-component reaction of ammonium acetate, p-methoxythiophenol, p-methoxybenzaldehyde and maleic anhydride. Structural diversity then arise...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3816122/ https://ncbi.nlm.nih.gov/pubmed/23682712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/co400049f |
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