A novel hypothesis: up-regulation of HO-1 by activation of PPARγ inhibits HMGB1-RAGE signaling pathway and ameliorates the development of ALI/ARDS

Suppression of inflammation in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) by activation of peroxisome proliferator-activated receptor (PPAR)-γ has been well demonstrated in animal model studies. However, the molecular mechanisms underlying this effect remain largely unkno...

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Bibliographic Details
Main Authors: Wang, Guizuo, Han, Dong, Zhang, Yonghong, Xie, Xinming, Wu, Yuanyuan, Li, Shaojun, Li, Manxiang
Format: Artigo
Language:Inglês
Published: Pioneer Bioscience Publishing Company 2013
Subjects:
Perspective
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815721/
https://ncbi.nlm.nih.gov/pubmed/24255785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3978/j.issn.2072-1439.2013.08.69
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