FOXO Transcription Factors Control E2F1 Transcriptional Specificity and Apoptotic Function

The transcription factor E2F1 is a key regulator of proliferation and apoptosis but the molecular mechanisms that mediate these cell fate decisions remain unclear. Here, we identify FOXO transcription factors as E2F1 target genes that act in a feed-forward regulatory loop to reinforce gene induction...

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Hlavní autoři: Shats, Igor, Gatza, Michael L., Liu, Beiyu, Angus, Steven P., You, Lingchong, Nevins, Joseph R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815650/
https://ncbi.nlm.nih.gov/pubmed/23966291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0453
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