An autocrine loop between TGF-β1 and the transcription factor Brachyury controls the transition of human carcinoma cells into a mesenchymal phenotype

The epithelial-mesenchymal transition (EMT) is a process associated with the metastasis of solid tumors as well as with the acquisition of resistance to standard anti-cancer modalities. A major initiator of EMT in carcinoma cells is TGF-β, which has been shown to induce the expression of several tra...

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Bibliographic Details
Main Authors: Larocca, Cecilia, Cohen, Joseph R., Fernando, Romaine I., Huang, Bruce, Hamilton, Duane H., Palena, Claudia
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815539/
https://ncbi.nlm.nih.gov/pubmed/23783250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1007
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