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Erythroid cells generated in the absence of specific β1-integrin heterodimers accumulate reactive oxygen species at homeostasis and are unable to mount effective antioxidant defenses

We have previously reported that β1(Δ/Δ) mice have a markedly impaired response to hemolytic stress, but the mechanisms of this were unclear. In the present study we explored in detail quantitative, phenotypic and functional aspects of erythropoiesis at homeostasis in a large number of animals for e...

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Main Authors: Ulyanova, Tatyana, Jiang, Yi, Padilla, Steven M., Papayannopoulou, Thalia
Format: Artigo
Jezik:Inglês
Izdano: Ferrata Storti Foundation 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3815179/
https://ncbi.nlm.nih.gov/pubmed/23812936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.087577
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