EZH2 mutations are frequent and represent an early event in follicular lymphoma

Gain of function mutations in the H3K27 methyltransferase EZH2 represent a promising therapeutic target in germinal center lymphomas. In this study, we assessed the frequency and distribution of EZH2 mutations in a large cohort of patients with follicular lymphoma (FL) (n = 366) and performed a long...

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Detalhes bibliográficos
Main Authors: Bödör, Csaba, Grossmann, Vera, Popov, Nikolay, Okosun, Jessica, O’Riain, Ciarán, Tan, King, Marzec, Jacek, Araf, Shamzah, Wang, Jun, Lee, Abigail M., Clear, Andrew, Montoto, Silvia, Matthews, Janet, Iqbal, Sameena, Rajnai, Hajnalka, Rosenwald, Andreas, Ott, German, Campo, Elias, Rimsza, Lisa M., Smeland, Erlend B., Chan, Wing C., Braziel, Rita M., Staudt, Louis M., Wright, George, Lister, T. Andrew, Elemento, Olivier, Hills, Robert, Gribben, John G., Chelala, Claude, Matolcsy, András, Kohlmann, Alexander, Haferlach, Torsten, Gascoyne, Randy D., Fitzgibbon, Jude
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814734/
https://ncbi.nlm.nih.gov/pubmed/24052547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-496893
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