Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice

Mice deleted for the plasminogen activator inhibitor-1 (PAI-1) gene are relatively protected from developing pulmonary fibrosis induced by bleomycin. We hypothesized that PAI-1 deficiency reduces fibrosis by promoting plasminogen activation and accelerating the clearance of fibrin matrices that accu...

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Bibliografiske detaljer
Main Authors: Hattori, Noboru, Degen, Jay L., Sisson, Thomas H., Liu, Hong, Moore, Bethany B., Pandrangi, Raj G., Simon, Richard H., Drew, Angela F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2000
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC381464/
https://ncbi.nlm.nih.gov/pubmed/11104787
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