Doxycycline Attenuated Pulmonary Fibrosis Induced by Bleomycin in Mice

The administration of doxycycline prior to bleomycin in mice attenuated pulmonary fibrosis. Bronchoalveolar neutrophil influx and gelatinase activity, but not caseinolytic activity, were attenuated by doxycycline. Established fibrosis was not affected by doxycycline. Thus, doxycycline might be usefu...

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Bibliographische Detailangaben
Hauptverfasser: Fujita, Masaki, Ye, Qing, Ouchi, Hiroshi, Harada, Eiji, Inoshima, Ichiro, Kuwano, Kazuyoshi, Nakanishi, Yoichi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
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Mechanisms of Action: Physiological Effects
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1366885/
https://ncbi.nlm.nih.gov/pubmed/16436734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.2.739-743.2006
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