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Atypical and Classical Forms of the Disease-Associated State of the Prion Protein Exhibit Distinct Neuronal Tropism, Deposition Patterns, and Lesion Profiles

A number of disease-associated PrP forms characterized by abnormally short proteinase K–resistant fragments (atypical PrPres) were recently described in prion diseases. The relationship between atypical PrPres and PrP(Sc), and their role in etiology of prion diseases, remains unknown. We examined th...

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Detalles Bibliográficos
Main Authors: Kovacs, Gabor G., Makarava, Natallia, Savtchenko, Regina, Baskakov, Ilia V.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814526/
https://ncbi.nlm.nih.gov/pubmed/24012784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.07.024
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