PCNA promotes processive DNA end resection by Exo1

Exo1-mediated resection of DNA double-strand break ends generates 3′ single-stranded DNA overhangs required for homology-based DNA repair and activation of the ATR-dependent checkpoint. Despite its critical importance in inducing the overall DNA damage response, the mechanisms and regulation of the...

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Bibliografiske detaljer
Main Authors: Chen, Xiaoqing, Paudyal, Sharad C., Chin, Re-I, You, Zhongsheng
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814391/
https://ncbi.nlm.nih.gov/pubmed/23939618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt672
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