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PCNA promotes processive DNA end resection by Exo1
Exo1-mediated resection of DNA double-strand break ends generates 3′ single-stranded DNA overhangs required for homology-based DNA repair and activation of the ATR-dependent checkpoint. Despite its critical importance in inducing the overall DNA damage response, the mechanisms and regulation of the...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3814391/ https://ncbi.nlm.nih.gov/pubmed/23939618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt672 |
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