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Distinct isoforms of the Drosophila Brd4 homologue are present at enhancers, promoters and insulator sites
Brd4 is a double bromodomain protein that has been shown to interact with acetylated histones to regulate transcription by recruiting Positive Transcription Elongation Factor b to the promoter region. Brd4 is also involved in gene bookmarking during mitosis and is a therapeutic target for the treatm...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3814382/ https://ncbi.nlm.nih.gov/pubmed/23945939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt722 |
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