Differential topical susceptibility to TGFβ in intact and injured regions of the epithelium: key role in myofibroblast transition

Induction of epithelial–myofibroblast transition (EMyT), a robust fibrogenic phenotype change hallmarked by α-smooth muscle actin (SMA) expression, requires transforming growth factor-β1 (TGFβ) and the absence/uncoupling of intracellular contacts. This suggests that an “injured” epithelium may be to...

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Hauptverfasser: Speight, Pam, Nakano, Hiroyasu, Kelley, Thomas J., Hinz, Boris, Kapus, András
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814143/
https://ncbi.nlm.nih.gov/pubmed/24006486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E13-04-0220
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