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The synthesis and antibacterial activity of doxycycline neoglycosides

A set of 37 doxycycline neoglycosides mediated via a C9 alkoxyamino-glycyl-based spacer reminiscent to that of tigecycline were prepared. The in vitro antibacterial assays against representative drug resistant Gram negative and Gram positive strains revealed a sugar-dependent activity profile and on...

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Detalhes bibliográficos
Main Authors: Zhang, Jianjun, Ponomareva, Larissa V., Marchillo, Karen, Zhou, Maoquan, Andes, David R., Thorson, Jon S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814126/
https://ncbi.nlm.nih.gov/pubmed/23987662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/np4003096
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