Sensitivity of Rabbit Ventricular Action Potential and Ca(2+) Dynamics to Small Variations in Membrane Currents and Ion Diffusion Coefficients

Little is known about how small variations in ionic currents and Ca(2+) and Na(+) diffusion coefficients impact action potential and Ca(2+) dynamics in rabbit ventricular myocytes. We applied sensitivity analysis to quantify the sensitivity of Shannon et al. model (Biophys. J., 2004) to 5%–10% chang...

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Autores principales: Lo, Yuan Hung, Peachey, Tom, Abramson, David, McCulloch, Andrew, Michailova, Anushka
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814049/
https://ncbi.nlm.nih.gov/pubmed/24222910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/565431
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