A One-Degree-of-Freedom Test for Supra-Multiplicativity of SNP Effects

Deviation from multiplicativity of genetic risk factors is biologically plausible and might explain why Genome-wide association studies (GWAS) so far could unravel only a portion of disease heritability. Still, evidence for SNP-SNP epistasis has rarely been reported, suggesting that 2-SNP models are...

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Detalhes bibliográficos
Main Authors: Herold, Christine, Ramirez, Alfredo, Drichel, Dmitriy, Lacour, André, Vaitsiakhovich, Tatsiana, Nöthen, Markus M., Jessen, Frank, Maier, Wolfgang, Becker, Tim
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3813579/
https://ncbi.nlm.nih.gov/pubmed/24205078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078038
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