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Golgi-associated RhoBTB3 targets Cyclin E for ubiquitylation and promotes cell cycle progression

Cyclin E regulates the cell cycle transition from G1 to S phase and is degraded before entry into G2 phase. Here we show that RhoBTB3, a Golgi-associated, Rho-related ATPase, regulates the S/G2 transition of the cell cycle by targeting Cyclin E for ubiquitylation. Depletion of RhoBTB3 arrested cells...

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Autores principales: Lu, Albert, Pfeffer, Suzanne R.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812982/
https://ncbi.nlm.nih.gov/pubmed/24145166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201305158
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