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Impaired growth and elevated Fas receptor expression in PIGA(+) stem cells in primary paroxysmal nocturnal hemoglobinuria
The genetic defect underlying paroxysmal nocturnal hemoglobinuria (PNH) has been shown to reside in PIGA, a gene that encodes an element required for the first step in glycophosphatidylinositol anchor assembly. Why PIGA-mutated cells are able to expand in PNH marrow, however, is as yet unclear. To a...
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| Gepubliceerd in: | J Clin Invest |
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| Hoofdauteurs: | , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Clinical Investigation
2000
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC381282/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10974022/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8328 |
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