Impaired growth and elevated Fas receptor expression in PIGA(+) stem cells in primary paroxysmal nocturnal hemoglobinuria

The genetic defect underlying paroxysmal nocturnal hemoglobinuria (PNH) has been shown to reside in PIGA, a gene that encodes an element required for the first step in glycophosphatidylinositol anchor assembly. Why PIGA-mutated cells are able to expand in PNH marrow, however, is as yet unclear. To a...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Chen, Rui, Nagarajan, Shanmugam, Prince, Gregory M., Maheshwari, Uma, Terstappen, Leon W.M.M., Kaplan, David R., Gerson, Stanton L., Albert, Jeffrey M., Dunn, Daniel E., Lazarus, Hillard M., Medof, M. Edward
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2000
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Article
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC381282/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10974022/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8328
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