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Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function
Current cancer vaccines induce tumor-specific T cell responses without sustained tumor regression because immunosuppressive elements within the tumor induce exhaustion of effector T cells and infiltration of immune-suppressive regulatory T cells (Tregs). Therefore, much effort has been made to gener...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3812678/ https://ncbi.nlm.nih.gov/pubmed/24014877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202752 |
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