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Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function

Current cancer vaccines induce tumor-specific T cell responses without sustained tumor regression because immunosuppressive elements within the tumor induce exhaustion of effector T cells and infiltration of immune-suppressive regulatory T cells (Tregs). Therefore, much effort has been made to gener...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Voo, Kui S., Bover, Laura, Harline, Megan L., Vien, Long T., Facchinetti, Valeria, Arima, Kazuhiko, Kwak, Larry W., Liu, Yong J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812678/
https://ncbi.nlm.nih.gov/pubmed/24014877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202752
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