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OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
Regulatory T (T reg) cells are the major obstacle to cancer immunotherapy, and their depletion promptly induces conversion of peripheral precursors into T reg cells. We show that T reg cells can be functionally inactivated by OX40 triggering. In tumors, the vast majority of CD4(+) T cells are Foxp3(...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2292222/ https://ncbi.nlm.nih.gov/pubmed/18362171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20071341 |
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