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Titration of GLI3 Repressor Activity by Sonic Hedgehog Signaling Is Critical for Maintaining Multiple Adult Neural Stem Cell and Astrocyte Functions

Sonic hedgehog (SHH), a key regulator of embryonic neurogenesis, signals directly to neural stem cells (NSCs) in the subventricular zone (SVZ) and to astrocytes in the adult mouse forebrain. The specific mechanism by which the GLI2 and GLI3 transcriptional activators (GLI2(A) and GLI3(A)) and repres...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Petrova, Ralitsa, Garcia, A. Denise R., Joyner, Alexandra L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812512/
https://ncbi.nlm.nih.gov/pubmed/24174682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2042-13.2013
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