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Conformational Flexibility of Helix VI is Essential for Substrate Permeation of the Human Apical Sodium-dependent Bile Acid Transporter (ASBT)
The present study characterizes the methanethiosulfonate (MTS) inhibition profiles of 26 consecutive cysteine-substituted mutants comprising transmembrane (TM) helix 6 of the human apical Na(+)-dependent bile acid transporter (hASBT, SLC10A2). TM6 is linked exofacially to TM7 via extracellular loop...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3812437/ https://ncbi.nlm.nih.gov/pubmed/17971420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.107.041640 |
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