Ligation Bias in Illumina Next-Generation DNA Libraries: Implications for Sequencing Ancient Genomes

Ancient DNA extracts consist of a mixture of endogenous molecules and contaminant DNA templates, often originating from environmental microbes. These two populations of templates exhibit different chemical characteristics, with the former showing depurination and cytosine deamination by-products, re...

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Bibliografiske detaljer
Main Authors: Seguin-Orlando, Andaine, Schubert, Mikkel, Clary, Joel, Stagegaard, Julia, Alberdi, Maria T., Prado, José Luis, Prieto, Alfredo, Willerslev, Eske, Orlando, Ludovic
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812280/
https://ncbi.nlm.nih.gov/pubmed/24205269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078575
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