Improving ancient DNA read mapping against modern reference genomes

BACKGROUND: Next-Generation Sequencing has revolutionized our approach to ancient DNA (aDNA) research, by providing complete genomic sequences of ancient individuals and extinct species. However, the recovery of genetic material from long-dead organisms is still complicated by a number of issues, in...

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Bibliografiske detaljer
Main Authors: Schubert, Mikkel, Ginolhac, Aurelien, Lindgreen, Stinus, Thompson, John F, AL-Rasheid, Khaled AS, Willerslev, Eske, Krogh, Anders, Orlando, Ludovic
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Methodology Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468387/
https://ncbi.nlm.nih.gov/pubmed/22574660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-13-178
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