Immunological effects of the TGFβ-blocking antibody GC1008 in malignant pleural mesothelioma patients

We evaluated a neutralizing anti-TGFβ antibody (GC1008) in cancer patients with malignant pleura mesothelioma (MPM). The goal of this study was to assess immunoregulatory effects in relation to clinical safety and clinical response. Patients with progressive MPM and 1–2 prior systemic therapies rece...

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Detalhes bibliográficos
Main Authors: Stevenson, James P, Kindler, Hedy L, Papasavvas, Emmanouil, Sun, Jing, Jacobs-Small, Mona, Hull, Jennifer, Schwed, Daniel, Ranganathan, Anjana, Newick, Kheng, Heitjan, Daniel F, Langer, Corey J, McPherson, John M, Montaner, Luis J, Albelda, Steven M
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812201/
https://ncbi.nlm.nih.gov/pubmed/24179709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.26218
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