Methylated DNA Binding Domain Protein 2 (MBD2) Coordinately Silences Gene Expression through Activation of the MicroRNA hsa-mir-496 Promoter in Breast Cancer Cell Line

Methylated DNA binding protein 2 (MBD2) binds methylated promoters and suppresses transcription in cis through recruitment of a chromatin modification repressor complex. We show here a new mechanism of action for MBD2: suppression of gene expression indirectly through activation of microRNA hsa-mir-...

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Hauptverfasser: Alvarado, Sebastian, Wyglinski, Joanne, Suderman, Matthew, Andrews, Stephen A., Szyf, Moshe
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812180/
https://ncbi.nlm.nih.gov/pubmed/24204564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074009
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