ZASC1 Stimulates HIV-1 Transcription Elongation by Recruiting P-TEFb and TAT to the LTR Promoter

Transcription from the HIV-1 LTR promoter efficiently initiates but rapidly terminates because of a non-processive form of RNA polymerase II. This premature termination is overcome by assembly of an HIV-1 TAT/P-TEFb complex at the transactivation response region (TAR), a structured RNA element encod...

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Main Authors: Bruce, James W., Reddington, Rachel, Mathieu, Elizabeth, Bracken, Megan, Young, John A. T., Ahlquist, Paul
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812036/
https://ncbi.nlm.nih.gov/pubmed/24204263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003712
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