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A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat
HIV-1 Tat binds human CyclinT1 and recruits the CDK9/P-TEFb complex to the viral TAR RNA in a step that links RNA polymerase II (RNAPII) C-terminal domain (CTD) Ser 2 phosphorylation with transcription elongation. Previous studies have suggested a connection between Tat and pre-mRNA splicing factors...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1132007/ https://ncbi.nlm.nih.gov/pubmed/15905409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1291705 |
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