Cellular Response to Trypanosoma cruzi Infection Induces Secretion of Defensin α-1, Which Damages the Flagellum, Neutralizes Trypanosome Motility, and Inhibits Infection

Human defensins play a fundamental role in the initiation of innate immune responses to some microbial pathogens. Here we show that colonic epithelial model HCT116 cells respond to Trypanosoma cruzi infection by secreting defensin α-1, which reduces infection. We also report the early effects of def...

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Detalhes bibliográficos
Main Authors: Johnson, Candice A., Rachakonda, Girish, Kleshchenko, Yuliya Y., Nde, Pius N., Madison, M. Nia, Pratap, Siddharth, Cardenas, Tatiana C., Taylor, Chase, Lima, Maria F., Villalta, Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811821/
https://ncbi.nlm.nih.gov/pubmed/23980110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01459-12
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