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Human Defensin α-1 Causes Trypanosoma cruzi Membrane Pore Formation and Induces DNA Fragmentation, Which Leads to Trypanosome Destruction

Human defensins play a fundamental role in the initiation of innate immune responses to some microbial pathogens. Here we show that human defensin α-1 displays a trypanocidal role against Trypanosoma cruzi, the causative agent of Chagas' disease. The toxicity of human defensin α-1 against T. cr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Madison, M. Nia, Kleshchenko, Yuliya Y., Nde, Pius N., Simmons, Kaneatra J., Lima, Maria F., Villalta, Fernando
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2044533/
https://ncbi.nlm.nih.gov/pubmed/17635867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00557-07
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