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Engineered Biosynthesis of Disaccharide-Modified Polyene Macrolides

Recent work has uncovered genes for two glycosyltransferases that are thought to catalyze mannosylation of mycosaminyl sugars of polyene macrolides. These two genes are nypY from Pseudonocardia sp. strain P1 and pegA from Actinoplanes caeruleus. Here we analyze these genes by heterologous expression...

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Main Authors: De Poire, Eimear, Stephens, Niamh, Rawlings, Bernard, Caffrey, Patrick
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811359/
https://ncbi.nlm.nih.gov/pubmed/23913424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02197-13
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