Transdermal Glyceryl Trinitrate as an Effective Adjunctive Treatment with Artemether for Late-Stage Experimental Cerebral Malaria

Cerebral malaria (CM) is associated with low nitric oxide (NO) bioavailability, cerebrovascular constriction, occlusion, and hypoperfusion. Administration of exogenous NO partially prevents the neurological syndrome and associated vascular pathology in an experimental CM (ECM) mouse model. In this s...

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Autori principali: Orjuela-Sánchez, Pamela, Ong, Peng Kai, Zanini, Graziela M., Melchior, Benoît, Martins, Yuri C., Meays, Diana, Frangos, John A., Carvalho, Leonardo J. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2013
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811294/
https://ncbi.nlm.nih.gov/pubmed/23979751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00488-13
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