Transdermal Glyceryl Trinitrate as an Effective Adjunctive Treatment with Artemether for Late-Stage Experimental Cerebral Malaria

Cerebral malaria (CM) is associated with low nitric oxide (NO) bioavailability, cerebrovascular constriction, occlusion, and hypoperfusion. Administration of exogenous NO partially prevents the neurological syndrome and associated vascular pathology in an experimental CM (ECM) mouse model. In this s...

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Detalhes bibliográficos
Main Authors: Orjuela-Sánchez, Pamela, Ong, Peng Kai, Zanini, Graziela M., Melchior, Benoît, Martins, Yuri C., Meays, Diana, Frangos, John A., Carvalho, Leonardo J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811294/
https://ncbi.nlm.nih.gov/pubmed/23979751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00488-13
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