Transdermal Glyceryl Trinitrate as an Effective Adjunctive Treatment with Artemether for Late-Stage Experimental Cerebral Malaria

Cerebral malaria (CM) is associated with low nitric oxide (NO) bioavailability, cerebrovascular constriction, occlusion, and hypoperfusion. Administration of exogenous NO partially prevents the neurological syndrome and associated vascular pathology in an experimental CM (ECM) mouse model. In this s...

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Hlavní autoři: Orjuela-Sánchez, Pamela, Ong, Peng Kai, Zanini, Graziela M., Melchior, Benoît, Martins, Yuri C., Meays, Diana, Frangos, John A., Carvalho, Leonardo J. M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811294/
https://ncbi.nlm.nih.gov/pubmed/23979751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00488-13
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