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EGFR-targeted diphtheria toxin stimulates TRAIL killing of glioblastoma cells by depleting anti-apoptotic proteins

Current treatments for Glioblastoma multiforme (GBM) involve surgery, radiotherapy, and cytotoxic chemotherapy; however, these treatments are not effective and there is an urgent need for better treatments. We investigated GBM cell killing by a novel drug combination involving DT-EGF, an Epidermal G...

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Detalhes bibliográficos
Main Authors: Horita, Henrick, Thorburn, Jacqueline, Frankel, Arthur E., Thorburn, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811048/
https://ncbi.nlm.nih.gov/pubmed/19449148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-009-9914-4
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