Diphtheria toxin mutant selectively kills cerebellar Purkinje neurons.

CRM107 (crossreacting material 107), a double point mutant of diphtheria toxin that lacks receptor-binding activity, specifically kills cerebellar Purkinje cells in vivo. After injection into guinea pig cerebrospinal fluid, CRM107 (0.9 micrograms) and CRM107-monoclonal antibody conjugates (10 microg...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Riedel, C J, Muraszko, K M, Youle, R J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54259/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2367523/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.13.5051
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