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Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice
We examine the impact of targeted disruption of growth hormone-releasing hormone (GHRH) in mice on longevity and the putative mechanisms of delayed aging. GHRH knockout mice are remarkably long-lived, exhibiting major shifts in the expression of genes related to xenobiotic detoxification, stress res...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3810783/ https://ncbi.nlm.nih.gov/pubmed/24175087 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01098 |
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