Myeloperoxidase-derived chlorinating species induce protein carbamylation through decomposition of thiocyanate and urea: Novel pathways generating dysfunctional high-density lipoprotein

AIM: Protein carbamylation through cyanate is thought to have a causal role in promoting cardiovascular disease. We recently observed that the phagocyte protein myeloperoxidase (MPO) specifically induces high-density lipoprotein carbamylation, rather than chlorination, in human atherosclerotic lesio...

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Main Authors: Holzer, Michael, Zangger, Klaus, El-Gamal, Dalia, Binder, Veronika, Curcic, Sanja, Konya, Viktoria, Schuligoi, Rufina, Heinemann, Akos, Marsche, Gunther
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3810648/
https://ncbi.nlm.nih.gov/pubmed/22462773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4403
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