IL-13 R110Q, a Naturally Occurring IL-13 Polymorphism, Confers Enhanced Functional Activity in Cultured Human Bronchial Smooth Muscle Cells

PURPOSE: Interleukin (IL)-13, a Th2-type cytokine, plays a pivotal role in the pathogenesis of asthma through its direct effects on airway smooth muscles. A naturally occurring IL-13 polymorphism, R110Q, is strongly associated with increased total serum IgE levels and asthma. In the present study, w...

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Main Authors: He, Ya-fang, Hua, Li, Bao, Yi-xiao, Liu, Quan-hua, Chu, Yi, Fang, Ding-zhu
Formato: Artigo
Idioma:Inglês
Publicado: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3810544/
https://ncbi.nlm.nih.gov/pubmed/24179684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4168/aair.2013.5.6.377
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