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Down regulation of hematopoietic MUC1 during experimental colitis increases tumor promoting myeloid-derived suppressor cells

PURPOSE: MUC1 is a tumor-associated antigen that is aberrantly expressed in cancer and inflammatory bowel disease (IBD). Even though immune cells express low MUC1 levels, their modulations of MUC1 are important in tumor progression. Consistent with previous clinical data that show increased myeloid-...

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Detalhes bibliográficos
Main Authors: Poh, Tze Wei, Madsen, Cathy S., Gorman, Jessica E., Marler, Ronald J., Leighton, Jonathan A., Cohen, Peter A., Gendler, Sandra J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3810272/
https://ncbi.nlm.nih.gov/pubmed/23873692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0278
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