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Monitoring antifolate resistance in intermittent preventive therapy for malaria

Mutations in the Plasmodium falciparum genes Pfdhfr and Pfdhps have rendered sulfadoxine-pyrimethamine (SP) ineffective for malaria treatment in most regions of the world. Yet, SP is efficacious as intermittent preventive therapy in pregnant women (IPTp) and infants (IPTi) and as seasonal malaria co...

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Bibliographic Details
Main Authors: Venkatesan, Meera, Alifrangis, Michael, Roper, Cally, Plowe, Christopher V.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3810209/
https://ncbi.nlm.nih.gov/pubmed/23948432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pt.2013.07.008
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