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Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1
The G2 DNA damage checkpoint delays mitotic entry via the upregulation of Wee1 kinase and the downregulation of Cdc25 phosphatase by Chk1 kinase, and resultant inhibitory phosphorylation of Cdc2. While checkpoint activation is well understood, little is known about how the checkpoint is switched off...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2004
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC381011/ https://ncbi.nlm.nih.gov/pubmed/14765108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600105 |
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