Runx3 regulates mouse TGF-β-mediated dendritic cell function and its absence results in airway inflammation

Runx3 transcription factor regulates cell lineage decisions in thymopoiesis and neurogenesis. Here we report that Runx3 knockout (KO) mice develop spontaneous eosinophilic lung inflammation associated with airway remodeling and mucus hypersecretion. Runx3 is specifically expressed in mature dendriti...

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Detalhes bibliográficos
Main Authors: Fainaru, Ofer, Woolf, Eilon, Lotem, Joseph, Yarmus, Merav, Brenner, Ori, Goldenberg, Dalia, Negreanu, Varda, Bernstein, Yael, Levanon, Ditsa, Jung, Steffen, Groner, Yoram
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC380997/
https://ncbi.nlm.nih.gov/pubmed/14765120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600085
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