Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant

Lumbar disc degeneration (LDD) is associated with both genetic and environmental factors and affects many people worldwide. A hallmark of LDD is loss of proteoglycan and water content in the nucleus pulposus of intervertebral discs. While some genetic determinants have been reported, the etiology of...

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Main Authors: Song, You-Qiang, Karasugi, Tatsuki, Cheung, Kenneth M.C., Chiba, Kazuhiro, Ho, Daniel W.H., Miyake, Atsushi, Kao, Patrick Y.P., Sze, Kit Ling, Yee, Anita, Takahashi, Atsushi, Kawaguchi, Yoshiharu, Mikami, Yasuo, Matsumoto, Morio, Togawa, Daisuke, Kanayama, Masahiro, Shi, Dongquan, Dai, Jin, Jiang, Qing, Wu, Chengai, Tian, Wei, Wang, Na, Leong, John C.Y., Luk, Keith D.K., Yip, Shea-ping, Cherny, Stacey S., Wang, Junwen, Mundlos, Stefan, Kelempisioti, Anthi, Eskola, Pasi J., Männikkö, Minna, Mäkelä, Pirkka, Karppinen, Jaro, Järvelin, Marjo-Riitta, O’Reilly, Paul F., Kubo, Michiaki, Kimura, Tomoatsu, Kubo, Toshikazu, Toyama, Yoshiaki, Mizuta, Hiroshi, Cheah, Kathryn S.E., Tsunoda, Tatsuhiko, Sham, Pak-Chung, Ikegawa, Shiro, Chan, Danny
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809787/
https://ncbi.nlm.nih.gov/pubmed/24216480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI69277
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